Ho Wang Tong, Hong Kong; and Connie Sau Kuen Kwok, Hong Kong.
Assigned to Nano and Advanced Materials Institute Limited, Hong Kong.

Filed: 10/19/17
Issued: 3/31/20

A membrane comprising a plurality of randomly oriented core-shell nanofibers, each of said core-shell nanofibers comprising: a non-polymeric nanofiber shell which is composed of one or more active ingredients and remains intact under a dry condition but is instantly dissolvable under a wet condition; and a polymeric nanofiber core comprising a polymer incorporated with one or more active ingredients which remains intact under either a dry or wet condition but is able to release the one or more active ingredients in a controlled release manner when said nanofiber shell is dissolved; wherein the one or more active ingredients in any of the non-polymeric nanofiber shell and the polymeric nanofiber core are small molecules having a molecular weight of 400 Da or below; and wherein said membrane is shifted with a shearing force of 500 mN or below when the non-polymeric nanofiber shell of the membrane is substantially dissolved during contact with a wet skin.